Novel Aproaches - Mucoadhesive Buccal Drug Delivery System

نویسندگان

  • Suhel khan
  • Nayyar Parvez
  • Pramod Kumar Sharma
  • Md Aftab Alam
  • Musarrat Husain Warsi
چکیده

Among novel drug delivery systems, Buccal mucoadhesive systems have attracted great attention in recent years due to their ability to adhere and remain on the oral mucosa and to release their drug content gradually. Mucoadhesion may be defined as the process where polymers attach to biological substrate or a synthetic or natural macromolecule, to mucus or an epithelial surface. Buccal mucoadhesive films can improve the therapeutic effect of drug by increasing the absorption of drug through oral mucosa which increases the drug bioavailability by reducing the hepatic first pass effect. Natural polymers have recently gained importance in pharmaceutical field. Mucoadhesive polymers are used to improve drug delivery by increasing the dosage form’s contact time and residence time with the mucous membranes. This review article deals with the novel approaches use in the buccal drug delivery systems.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Pharma Science Monitor an International Journal of Pharmaceutical Sciences a Review on Mucoadhesive Buccal Patch as a Novel Drug Delivery System

Department of Pharmaceutical Technology, Meerut Institute of Engineering & Technology, NH-58, Baghpat Road-Bypass Crossing, Meerut-250005 (U.P), India ABSTRACT Drug release from mucoadhesive patches at predetermined rate in oral cavity having distinct advantages over traditional dosage forms as tablets, gels and solutions. This review provides brief information about method of preparation and e...

متن کامل

In-vitro and In-vivo Evaluation of Novel Mucoadhesive Buccal Drug Delivery Systems-a Review

The buccal mucosa is one of the administration sites that might provide an alternative for peroral administration. Mucoadhesive buccal drug delivery systems is one of the most important novel drug delivery systems with its various advantages and it has a lot of potential in formulating dosage forms for various chronic diseases. The delivery of drugs through the buccal mucosa has attracted much ...

متن کامل

Drug Delivery Based on Buccal Adhesive Systems - a Review

Buccal delivery involves the administration of the desired drug through the buccal mucosal membrane lining of the oral cavity.The objective of this article is to review buccal drug delivery by discussing the structure and environment of the oral mucosa and highlighting the mechanisms of drug permeation and methodology in evaluating buccal formulations. This review also highlights a brief descri...

متن کامل

Propranolol Hydrochloride Buccoadhesive Tablet: Development and In-vitro Evaluation

Purposes: Propranolol HCl is a beta blocker commonly used worldwide; however, it shows a low bioavailability due to its extensive first-pass metabolism. To solve this problem, a novel drug delivery system such as buccoadhesive system might be helpful. The aim of the present investigation is to prepare the buccoadhesive tablet of propranolol HCl using different mucoadhesive polymers. Method: Buc...

متن کامل

Mucoadhesive Microspheres-A Promising Carrier in Drug Delivery: A Review

Corresponding Authors: Sellappan Velmurugan Email: [email protected] Abstract: Carrier technology offers a promising approach for drug delivery system by coupling the drug to a carrier particle such as microspheres,nanoparticles, niosomes, liposomes etc. which modulates the release characteristics of the drug. Mucoadhesion had been a topic of interest in the design of novel drug delive...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2016